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Schistocytes and thrombocytopenia

Schistocytes and thrombocytopenia

Schistocytes (->) and thrombocytopenia in a patient with haemolytic uraemic syndrome (HUS). This disease, as well as for example thrombotic thrombocytopenic purpura (TTP), is a so-called 'microangiopathic haemolytic anaemia' (MAHA). Characteristic of MAHA is a responsive increase in the production of red blood cells and platelets whose immature precursors (reticulocytes and immature platelet fraction, IPF) can be measured on certain Sysmex analysers. On a blood film the differential diagnosis of MAHA is not possible.

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