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Haemostasis Measurement Technologies

 

 

Immunoassay & Platelet Aggregation

The sample-reagent mixture contains artificial particles that can aggregate when there is an antigen-antibody reaction or particles that have a natural capability to aggregate like platelets. The mixture is exposed to light of a high wavelength, and the change in light absorbance caused by the formation of aggregates is detected as the change in transmitted light. This is used for D-dimer assays and platelet aggregation assays (VWF:RCof, ADP, Collagen, Arachidonic Acid, Epinephrine).

Chromogenic Method

Light of a specific wavelength is directed at the sample and reagent mixture and detected by a photodiode, where the transmitted light is converted into electrical signals. The change in the intensity of this transmitted light is used to determine the change in absorbance. This measurement is used for chromogenic assays like Antithrombin and Protein C where a chromogenic substrate in presence of an activator causes the reagent mixture to change colour.

Clotting Method

The Optical Detection Method on the CS-5100 detects the change in turbidity of the sample-reaction mixture during the coagulation process. This is reflected in the change in scattered light intensity when fibrinogen is converted into a fibrin mesh. Light strikes the reaction mixture, after the scattered light intensity is received by a photodiode. This converts the light intensity into electrical signals and is used to find the coagulation time. This method is used to measure prothrombin time, APTT, fibrinogen, factors and many other clotting tests.

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