Sysmex CS-5100


  • Exceptional throughput of up to 400 tests per hour
  • Compatible with Laboratory Automation Systems (LAS)
  • Pre-analytical sample integrity check for primary sample volume and interfering substances
  • Powerful multi-wavelength technology for up to 60 parameters
  • Efficient workflow, rapid turnaround and simultaneous random access


  • All
  • Brochure

CS-5100 - Outstanding Haemostasis Analysis

With a throughput of up to 400 tests per hour, the CS-5100 delivers high quality results in a very short timeframe. With its powerful multi-wavelength technology, it has 20 channels for clotting, chromogenic and immunoassays and 8 for platelet aggregation with automatic stirring.

The CS-5100 will validate the integrity of the sample by checking the primary sample volume and that there are no significant levels of interfering substances present.

Pre-analytical sample checks significantly eliminate manual processes and allows secure connections to larger laboratory solutions. Advanced reagent management makes use of simplified software, and an auto QC on vial change significantly diminishes the risk of errors. 

No compromise on quality

No compromise on quality

Using four different detection technologies, the CS-5100 delivers great quality analyses. With clotting, chromogenic, immunoturbimetric and platelet aggregation assays it delivers accuracy and precision for all parameters.

Clotting method

At the beginning of the clotting reaction, a baseline reading is taken and designed as 0%. The transmitted light is monitored for a set length of time with the detected end-point set at 100%. The calculated end-point can be set between 1% and 99%. The CS-5100 uses the 50% point as standard; at which the amount of light transmitted per unit time shows the greatest change and the fibrin monomer polymerisation reaction rate is high.

Chromogenic method

Light of a specific wavelength is directed at the sample and reagent mixture and detected by a photodiode, where the transmitted light is converted into electrical signals. The change in the intensity of this transmitted light is used todetermine the change in absorbance. This measurement is used for chromogenic assays like Antithrombin and Protein C where chromogenic substrate in presence of an activator causes the reagent mixture to change colour. 

Immunoassay and platelet aggregation method

The sample-reagent mixture contains artificial particles that can aggregate when there is an antigen-antibody reaction or particles that have a natural capability to aggregate like platelets. The mixture is exposed to light of a high wavelength, and the change in light absorbance caused by the formation of aggregates is detected as the change in transmitted light. This is used for D-dimer assays and platelet aggregation assays (Von Willebrand activity, ADP, Collagen, Arachidonic Acid, Epinephrine).

Get it right before you start testing – pre-analytical sample integrity

Get it right before you start testing – pre-analytical sample integrity

Pre-analytical issues can account for as much as 70% of a clinical laboratory’s errors. Multi-wavelength scanning and sample liquid-sensing technologies detect unsuitable specimens. A pre-analytical sample integrity check tests for interfering substances in the sample – haemolysis, icterus, lipaemia – at three wavelengths: 405 nm, 575 nm and 660 nm.

In addition, a primary tube sample volume check provides assistance by identifying potential inaccuracies caused by improper sample collection, which can result in an incorrect ratio of anticoagulant to patient plasma.

Under specific conditions, the CS-5100 will automatically use the optimal wavelengths to ensure result accuracy in the presence of lipaemia.  hemolysis, icterus or lipemia. This minimises the need for retesting and helps you deliver the highest quality results on your first test run.

Multi-wave detection - reduce your repeat tests

Multi-wave detection - reduce your repeat tests

The multi-wave detection system available on the CS-5100 can simultaneously measure multiple parameters using four different measurement methods: coagulation, chromogenic, immunoassay and aggregation. The system’s photo-optical clot detection means you have several advantages compared to mechanical detection.

  • You can measure light transmittance over the entire course of clot formation, not just the end.
  • You can identify atypical reaction patterns easily and so determine the correct coagulation reaction result for your patients with unusual in vitro clot reactions such as sepsis and DIC.
  • The clotting reactions display the complete clot signature, not just a single data point, so that you get far more detailed test information and therefore better clinical utility.
  • Used on a single platform, the broad range of assays allows high test throughput – up to 400 samples per hour.
Cooled reagent system – flexible and cost-efficient

Cooled reagent system – flexible and cost-efficient

Reagent racks are placed in a double-ring reagent table capable of handling a total of 40 reagent bottles maintained at 10°C. The reagent management on the CS-5100 is both easy to use and very secure. All reagents can be identified using a reagent barcode which is read in-situ negating the risk of position errors. The system will automatically read the position, reagent type, batch number and vial size. The volume is detected by the probe and displayed on the screen numerically and diagrammatically, along with the number of tests remaining and time on-board.

All cooled reagents can be placed in any position in the cooler- there are no restrictions- allowing simple loading of reagents for all staff grades. This means that all reagent positions can realistically be used at the same time, if required.

The bottles are slightly tilted to reduce dead volume and reagent waste and maximise the number of tests per vial. One position on each reagent rack can stir reagents so you can use reagents that require continuous mixing,

Overall, the CS-5100 can potentially cut your costs by optimising the use of our reagents. You can maximise the number of tests per vial through tilting and greater stability thanks to cooling and reduced evaporation.

Superior calibration and assay performance

Superior calibration and assay performance

  • Convenient batch change with maximum security
  • Accessibility for all users with standardised decision-making
  • Excellent linearity negating multiple calibrations for different assay ranges
  • Up to 12 dilution points for each calibration performed
  • Up to 10 live calibration curves per assay
  • Automatic recognition of the appropriate calibration curve




Detection principles

Multi-wavelength detector for transmitted light at

340, 405, 575, 660 and 800 nm 

Detection methods

20 channels for clotting, chromogenic and immunoassays; 8 channels for platelet aggregation


Up to 60 parameters can be analysed simultaneously.

View Parameters


Up to 400 tests/hr


Rack type, auto sampler, cap piercing functionality, initial capacity for 10 racks with 10 sample tubes each, continuous loading facility;5 separate STAT positions

Reagent holder

40 positions cooled at 10 °C; 5 positions at room temperature; all positions with positive reagent identification. Any reagent anywhere within the cooled reagent table.

Reference curves

Multi-lot management with maximum 10 curves per reagent lot and maximum 10 reagent lots per parameter

Quality control

Levey-Jennings and Westgard control

750 parameter files with max. 1,200 data points each

Data storage

up to 10,000 samples

Dimensions & Weight

Dimensions & Weight

Main unit*: approx. 1030mm (w) x 1150mm (d)  x 1350mm (d) /267Kg

IPU with cabinet: approx. 500mm (w) x 890mm (d) x 920mm (d) /67Kg


*excluding optional features, such as direct sampling, which will alter the dimensions.

Create Pdf

CS-5100 Coagulation System

See the features
Enjoy our Media Centre
  • All
  • Documents
  • Podcast
  • Images
  • Videos
Sysmex Urinalysis
See the features