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Sysmex Life Science Goes Blue

CRC is the third most common cancer in the world and one of the leading causes of cancer-related deaths. It affects men and women and it’s the second leading cancer killer in Europe.1 What sets colorectal cancer apart from other cancers is the ease and convenience of early screening and with this, the chance to reduce mortality across the globe.

Most colon cancer start as polyps and FIT test helps to find blood in stool even before they turn into cancer. If detected at an early stage, a cancerous polyp can usually be removed, and the chance of advanced-stage cancer greatly reduced.

Early detection, individualization of cancer therapy, and the use of less invasive diagnostics are leading to improved prognoses as well as Patients’ quality of life.2 Identifying the cancer early on is especially important for therapeutic success. Screening – both symptomatic and especially large-scale – is essential.

We are playing a significant role in these improvements and everything we offer is uniquely designed to address the needs of lab managers and clinician that address the prevention, diagnosis and treatment of colorectal cancer disease. Finally, to improve the lives of the patient they serve.

Prevention

Colorectal cancer prevention with the FIT screening test

Early detection of colorectal cancer is key

Colorectal cancer (CRC) is increasing globally, but the potential for a full recovery is known to increase when it is discovered early. This is why early screening is extremely important. 

One of the most reliable early-detection methods for colorectal cancer and its preliminary stages is the faecal immunological test (FIT).

A potential sign of colorectal cancer can be intestinal bleeding, which the FIT can identify – even in the smallest amounts of blood in the stool. If the findings are positive, further diagnostic actions can be undertaken at an early stage.

Various studies have shown that the detection rate for the FIT compares very well with colonoscopy. Our test and associated screening programme are already being used in several European national and regional colorectal cancer prevention programmes.

The FIT test kit (SENTiFIT pierceTube), stool sampling is easy, stress-free and can be performed comfortably at home. The sample is then analysed in a laboratory and the patient will be informed about his test results soon afterwards. Screening with the FIT test is simple and quick and no big deal except for the huge relief your patients feel afterwards.

We offer faecal immunochemical test (FIT) kits for two main audiences: large-scale screening programmes (rule-in testing) and testing of symptomatic patients (rule-out testing) in hospital or clinical routine settings. For more information on the FIT solution visit our Microsite here.

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Diagnosis

Cancer diagnosis with OSNA

Cancer staging is the step that determines the type and extent of treatment. An essential part of this staging process is assessment of the nodal status.

Revealing the whole picture

Lymph node status is the most important prognostic factor and staging parameter in colorectal cancer management. The current histopathological method consists of the analysis of less than 2% of the total lymph node tissue. As a result, metastases may remain undetected, leading to false-negative results and a higher risk of disease recurrence.

OSNA (one step nucleic acid amplification) allows fast, sensitive and standardised lymph node analysis, enabling accurate staging and avoiding false-negative results. By analysing the entire lymph node, the OSNA method provides a reliable basis for decisions on adjuvant therapy, avoiding understaging and thus preventing undertreatment of patients.

OSNA improves patients’ quality of life by providing an accurate and fast diagnosis, reducing risk of undertreatment and decreasing overall patient stress.

For more information on our OSNA solution visit our website.

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Treatment

CRC treatment solutions - precisely brings to light what needs to be seen

Precision diagnostics are key to selecting the right therapy at the right time for the right cancer patient.

Gene alterations play a key role during the onset and development of colorectal cancer.1 Therefore, reliable assessment of the tumour’s mutational status is decisive not only in selecting cancer patients eligible for targeted therapy, but also later on, to monitor response to treatment and disease progression.

Nowadays, a range of medications targeting tumour-specific genetic alterations are available, and can be prescribed instead of, or in combination with, standard chemotherapies and radiotherapies. To investigate such genetic changes, oncologists can make use of a variety of molecular genetic tests which may support them in making personalised treatment decisions.

Sysmex offers a range of products based on cutting-edge molecular biology technologies supporting heath care professionals and patients along the whole pathway of care.

Molecular tests for therapy selection

With CytoCell FISH (Fluorescent In Situ Hybridization) probes for MET and EGFR genes, oncologists will get specific information on colorectal cancer prognosis and indication for EGFR-inhibitor medications (e.g. gefitinib, erlotinib and lapatinib).2

Other critical and currently relevant colorectal cancer genes including KRAS, NRAS, APC, TP53, ERBB2, PTEN and BRAF can be investigated by Next Generation Sequencing tests, with the Sysmex solution in this case being the SureSeq myPanelTM* NGS Custom Colorectal Cancer Panel.

For further information visit SureSeq myPanel™ NGS Custom Colorectal Cancer Panel website

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Liquid biopsy for monitoring

Analysing genetic mutations in biopsied tissue has been the standard in clinical oncology, despite its inconvenience and risks of clinical complications for the patients.3 Moreover, biopsies are subject to selection bias due to tumour heterogeneity, can be difficult to obtain in sufficient amounts and the information provided is restricted to a static time point.4,5 Here, liquid biopsy analysis of mutations in cell-free tumour DNA (ctDNA) has become a valuable tool for a variety of clinical and investigative applications. The detection of clinically relevant mutations from a simple blood draw enables clinicians to select the most beneficial therapy and monitor the patient’s response to therapy in real time.

* SureSeq myPanelTM: For research use only; not for use in diagnostic procedures.

References
1) Ogunwobi, O.O.; Mahmood, F.; Akingboye, A. Biomarkers in Colorectal Cancer: Current Research and Future Prospects Int. J. Mol. Sci. 2020, 21, 5311
2) Hegymegi-Barakonyi B, Tyrosine kinase inhibitors - small molecular weight compounds inhibiting EGFR Curr Opin Mol Ther 2009;11(3):308-21
3) Overman MJ, Modak J, Kopetz S, et al: Use of research biopsies in clinical trials: Are risks and benefits adequately discussed? J Clin Oncol 31:17-22, 2013
4) Vogelstein B, Papadopoulos N, Velculescu VE, et al: Cancer genome landscapes. Science 339:1546-1558, 2013
5) Gerlinger M, Rowan AJ, Horswell S, et al: Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 366:883-892, 2012

Read three inspiring colorectal cancer survivor stories. They share words of inspiration, hope and how their lives have been changed by this disease.

References

1) WHO (2021): https://gco.iarc.fr/today/data/factsheets/cancers/10_8_9-Colorectum-fact-sheet.pdf

2) Lee J.J. et al.(2016): Options for Second-Line Treatment in Metastatic Colorectal Cancer. Clinical Advances in Hematology & Oncology, 14(1):46-54.

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